increased splenocyte apoptosis_Polb<tm1.1Jbsw>/Polb<tm1.1Jbsw>

http://metadb.riken.jp/0009322I129SvC57BL6Polbtm11JbswPolbtm11JbswPolbtm11Jbsw

increased splenocyte apoptosis_Polb<tm1.1Jbsw>/Polb<tm1.1Jbsw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• polymerase (DNA directed), beta
  http://metadb.riken.jp/db/mgi_rdf/MGI:97740

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Polb<tm1.1Jbsw>/Polb<tm1.1Jbsw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Polb<tm1.1Jbsw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased splenocyte apoptosis
  http://purl.obolibrary.org/obo/MP_0009322

文献

http://purl.org/net/cito/citesAsAuthority

• Alireza G. Senejani, et.al., Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/22493258
• Alireza G. Senejani, et.al., Mutation of POLB causes lupus in mice., Cell reports, 2014, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/24388753