increased sensitivity to xenobiotic induced morbidity/mortality_Tpmt<tm1Rlng>/Tpmt<+>

http://metadb.riken.jp/0009766I129P2OlaHsdC57BL6NMRITpmttm1RlngTpmtTpmtTpmttm1Rlng

increased sensitivity to xenobiotic induced morbidity/mortality_Tpmt<tm1Rlng>/Tpmt<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• thiopurine methyltransferase
  http://metadb.riken.jp/db/mgi_rdf/MGI:98812

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tpmt<tm1Rlng>/Tpmt<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tpmt<+>|Tpmt<tm1Rlng>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * NMRI

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased sensitivity to xenobiotic induced morbidity/mortality
  http://purl.obolibrary.org/obo/MP_0009766

文献

http://purl.org/net/cito/citesAsAuthority

• Christine. Hartford, et.al., Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics., Cancer research, 2007, 67
  http://rdf.ncbi.nlm.nih.gov/pubmed/17510427