increased sensitivity to xenobiotic induced morbidity/mortality_Ptgs2<tm1Unc>/Ptgs2<tm1Unc>

http://metadb.riken.jp/0009766I129P2OlaHsdC57BL6Ptgs2tm1UncPtgs2tm1UncPtgs2tm1Unc

increased sensitivity to xenobiotic induced morbidity/mortality_Ptgs2<tm1Unc>/Ptgs2<tm1Unc>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• prostaglandin-endoperoxide synthase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97798

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptgs2<tm1Unc>/Ptgs2<tm1Unc>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptgs2<tm1Unc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased sensitivity to xenobiotic induced morbidity/mortality
  http://purl.obolibrary.org/obo/MP_0009766

文献

http://purl.org/net/cito/citesAsAuthority

• O. Morteau, et.al., Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2., The Journal of clinical investigation, 2000, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/10683376
• Tomo-O. Ishikawa, et.al., Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression., Carcinogenesis, 2010, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/20061361