decreased prostaglandin level_Nos3<tm1Plh>/Nos3<tm1Plh>,Ptgs1<tm1Unc>/Ptgs1<tm1Unc>

http://metadb.riken.jp/0009815I129P2OlaHsd129S4SvJaeC57BL6Nos3tm1PlhNos3tm1PlhPtgs1tm1UncPtgs1tm1UncPtgs1tm1UncNos3tm1Plh

decreased prostaglandin level_Nos3<tm1Plh>/Nos3<tm1Plh>,Ptgs1<tm1Unc>/Ptgs1<tm1Unc>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• prostaglandin-endoperoxide synthase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97797
• nitric oxide synthase 3, endothelial cell
  http://metadb.riken.jp/db/mgi_rdf/MGI:97362

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nos3<tm1Plh>/Nos3<tm1Plh>,Ptgs1<tm1Unc>/Ptgs1<tm1Unc>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptgs1<tm1Unc>|Nos3<tm1Plh>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased prostaglandin level
  http://purl.obolibrary.org/obo/MP_0009815

文献

http://purl.org/net/cito/citesAsAuthority

• Ramona S. Scotland, et.al., Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo., Circulation, 2005, 111
  http://rdf.ncbi.nlm.nih.gov/pubmed/15699263