decreased prostaglandin level_Ptgs1<tm1Unc>/Ptgs1<tm1Unc>

http://metadb.riken.jp/0009815I129P2OlaHsdC57BL6Ptgs1tm1UncPtgs1tm1UncPtgs1tm1Unc

decreased prostaglandin level_Ptgs1<tm1Unc>/Ptgs1<tm1Unc>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• prostaglandin-endoperoxide synthase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97797

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptgs1<tm1Unc>/Ptgs1<tm1Unc>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptgs1<tm1Unc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased prostaglandin level
  http://purl.obolibrary.org/obo/MP_0009815

文献

http://purl.org/net/cito/citesAsAuthority

• Jacqueline K. Akunda, et.al., Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/14630706
• M G. Camitta, et.al., Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning., Circulation, 2001, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/11705824
• O. Morteau, et.al., Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2., The Journal of clinical investigation, 2000, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/10683376
• R. Langenbach, et.al., Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration., Cell, 1995, 83
  http://rdf.ncbi.nlm.nih.gov/pubmed/8521478
• G A. Gross, et.al., Opposing actions of prostaglandins and oxytocin determine the onset of murine labor., Proceedings of the National Academy of Sciences of the United States of America, 1998, 95
  http://rdf.ncbi.nlm.nih.gov/pubmed/9751758