increased total body fat amount_Gt(ROSA)26Sor<tm2(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0

http://metadb.riken.jp/0010024I129S4SvJaeC57BL6DBA2FVBNGtROSA26Sortm2Foxo1JnkGtROSA26SorPdpk1tm1MakaPdpk1tm1MakaTgCAGcatlacZ11Miya0TgPomc1cre16Lowl0Pdpk1tm1MakaGtROSA26Sortm2Foxo1JnkGtROSA26SorTgCAGcatlacZ11MiyaTgPomc1cre16Lowl

increased total body fat amount_Gt(ROSA)26Sor<tm2(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• 3-phosphoinositide dependent protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338068
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 16, Bradford B Lowell
  http://metadb.riken.jp/db/mgi_rdf/MGI:3640615
• transgene insertion 11, Jun-ichi Miyazaki
  http://metadb.riken.jp/db/mgi_rdf/MGI:3762382

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm2(Foxo1)Jnk>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Maka>/Pdpk1<tm1Maka>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pdpk1<tm1Maka>|Gt(ROSA)26Sor<tm2(Foxo1)Jnk>|Gt(ROSA)26Sor<+>|Tg(CAG-cat-lacZ)11Miya|Tg(Pomc1-cre)16Lowl

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased total body fat amount
  http://purl.obolibrary.org/obo/MP_0010024

文献

http://purl.org/net/cito/citesAsAuthority

• Kristy. Iskandar, et.al., PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake., American journal of physiology. Endocrinology and metabolism, 2010, 298
  http://rdf.ncbi.nlm.nih.gov/pubmed/20103739