increased total body fat amount_Mc4r<tm2Lowl>/Mc4r<tm2Lowl>,Tg(Sim1-cre)1Lowl/0

http://metadb.riken.jp/0010024I129S4SvJaeSor129S6SvEvTacC57BL6FVBNMc4rtm2LowlMc4rtm2LowlTgSim1cre1Lowl0Mc4rtm2LowlTgSim1cre1Lowl

increased total body fat amount_Mc4r<tm2Lowl>/Mc4r<tm2Lowl>,Tg(Sim1-cre)1Lowl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Bradford B Lowell
  http://metadb.riken.jp/db/mgi_rdf/MGI:3692524
• melanocortin 4 receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:99457

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mc4r<tm2Lowl>/Mc4r<tm2Lowl>,Tg(Sim1-cre)1Lowl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mc4r<tm2Lowl>|Tg(Sim1-cre)1Lowl

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased total body fat amount
  http://purl.obolibrary.org/obo/MP_0010024

文献

http://purl.org/net/cito/citesAsAuthority

• Bhavik P. Shah, et.al., MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111
  http://rdf.ncbi.nlm.nih.gov/pubmed/25157144