abnormal synaptic dopamine release_Chrna4<tm1.1Tmcg>/Chrna4<tm1.1Tmcg>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>

http://metadb.riken.jp/0010149I129SSvEv129S1SvC57BL6Chrna4tm11TmcgChrna4tm11TmcgSlc6a3tm1creXzSlc6a3Chrna4tm11TmcgSlc6a3tm1creXzSlc6a3

abnormal synaptic dopamine release_Chrna4<tm1.1Tmcg>/Chrna4<tm1.1Tmcg>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cholinergic receptor, nicotinic, alpha polypeptide 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:87888
• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Chrna4<tm1.1Tmcg>/Chrna4<tm1.1Tmcg>,Slc6a3<tm1(cre)Xz>/Slc6a3<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Chrna4<tm1.1Tmcg>|Slc6a3<tm1(cre)Xz>|Slc6a3<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * 129S1/Sv * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal synaptic dopamine release
  http://purl.obolibrary.org/obo/MP_0010149

文献

http://purl.org/net/cito/citesAsAuthority

• Tresa M. McGranahan, et.al., α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21795541