increased mammary gland epithelial cell proliferation_Pik3ca<tm1.1Waph>/Pik3ca<+>,Tg(MMTV-cre)#Mam/0

http://metadb.riken.jp/0010173I129S1SvC57BL6FVBPik3catm11WaphPik3caTgMMTVcreMam0Pik3catm11WaphPik3caTgMMTVcreMam

increased mammary gland epithelial cell proliferation_Pik3ca<tm1.1Waph>/Pik3ca<+>,Tg(MMTV-cre)#Mam/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:1206581
• transgene insertion, Lothar Hennighausen
  http://metadb.riken.jp/db/mgi_rdf/MGI:3802641

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pik3ca<tm1.1Waph>/Pik3ca<+>,Tg(MMTV-cre)#Mam/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pik3ca<tm1.1Waph>|Pik3ca<+>|Tg(MMTV-cre)#Mam

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * C57BL/6 * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary gland epithelial cell proliferation
  http://purl.obolibrary.org/obo/MP_0010173

文献

http://purl.org/net/cito/citesAsAuthority

• Anjali. Tikoo, et.al., Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors., PloS one, 2012, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/22666336