increased melanoma incidence_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Pten<tm1Rps>/Pten<tm1Rps>,Tg(Tyr-cre/ERT2)13Bos/0

http://metadb.riken.jp/0010275I129SvC57BL6JFVBSJLCdkn2atm1RdpCdkn2atm1RdpCtnnb1tm1MmtCtnnb1tm1MmtPtentm1RpsPtentm1RpsTgTyrcreERT213Bos0Cdkn2atm1RdpPtentm1RpsTgTyrcreERT213BosCtnnb1tm1Mmt

increased melanoma incidence_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Pten<tm1Rps>/Pten<tm1Rps>,Tg(Tyr-cre/ERT2)13Bos/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 13, Marcus Bosenberg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3641202
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Pten<tm1Rps>/Pten<tm1Rps>,Tg(Tyr-cre/ERT2)13Bos/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2a<tm1Rdp>|Pten<tm1Rps>|Tg(Tyr-cre/ERT2)13Bos|Ctnnb1<tm1Mmt>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6J * FVB * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased melanoma incidence
  http://purl.obolibrary.org/obo/MP_0010275

文献

http://purl.org/net/cito/citesAsAuthority

• Matthew A. Held, et.al., Characterization of melanoma cells capable of propagating tumors from a single cell., Cancer research, 2010, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/20048081