increased mammary gland tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Trp53<tm1Brd>/Trp53<+>,Tg(MMTV-cre)4Mam/0

http://metadb.riken.jp/0010299I129S6SvEvTac129S7SvEvBrdBlackSwissFVBBrca1tm1CxdBrca1tm2CxdTrp53tm1BrdTrp53TgMMTVcre4Mam0Trp53tm1BrdBrca1tm1CxdBrca1tm2CxdTgMMTVcre4MamTrp53

increased mammary gland tumor incidence_Brca1<tm1Cxd>/Brca1<tm2Cxd>,Trp53<tm1Brd>/Trp53<+>,Tg(MMTV-cre)4Mam/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 4, Lothar Hennighausen
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176163

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm1Cxd>/Brca1<tm2Cxd>,Trp53<tm1Brd>/Trp53<+>,Tg(MMTV-cre)4Mam/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>|Brca1<tm1Cxd>|Brca1<tm2Cxd>|Tg(MMTV-cre)4Mam|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary gland tumor incidence
  http://purl.obolibrary.org/obo/MP_0010299

文献

http://purl.org/net/cito/citesAsAuthority

• X. Xu, et.al., Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation., Nature genetics, 1999, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/10319859