increased skin tumor incidence_Trp53<tm1.1Brn>/Trp53<tm3Tyj>,Tg(KRT14-cre)8Brn/?

http://metadb.riken.jp/0010300I129P2OlaHsd129S4SvJaeFVBNSKH1Trp53tm11BrnTrp53tm3TyjTgKRT14cre8BrnTrp53tm3TyjTrp53tm11BrnTgKRT14cre8Brn

increased skin tumor incidence_Trp53<tm1.1Brn>/Trp53<tm3Tyj>,Tg(KRT14-cre)8Brn/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Trp53<tm1.1Brn>/Trp53<tm3Tyj>,Tg(KRT14-cre)8Brn/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm3Tyj>|Trp53<tm1.1Brn>|Tg(KRT14-cre)8Brn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N * SKH1

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased skin tumor incidence
  http://purl.obolibrary.org/obo/MP_0010300

文献

http://purl.org/net/cito/citesAsAuthority

• Susan W P. Wijnhoven, et.al., Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage., Cancer research, 2007, 67
  http://rdf.ncbi.nlm.nih.gov/pubmed/17510390