increased skin tumor incidence_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

http://metadb.riken.jp/0010300I129P2OlaHsdFVBNTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnTgKRT14cre8Brn

increased skin tumor incidence_Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Tg(KRT14-cre)8Brn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased skin tumor incidence
  http://purl.obolibrary.org/obo/MP_0010300

文献

http://purl.org/net/cito/citesAsAuthority

• Patrick W B. Derksen, et.al., Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis., Cancer cell, 2006, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/17097565
• Xiaoling. Liu, et.al., Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer., Proceedings of the National Academy of Sciences of the United States of America, 2007, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/17626182