decreased tumor latency_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm3Tyj>/Trp53<+>,Wap<tm1(cre)Arge>/Wap<+>

http://metadb.riken.jp/0010308I129S1Sv129S4SvJae129S6SvEvTacC57BL6Brca1tm21CxdBrca1tm21CxdTrp53tm3TyjTrp53Waptm1creArgeWapTrp53tm3TyjWaptm1creArgeBrca1tm21CxdWapTrp53

decreased tumor latency_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm3Tyj>/Trp53<+>,Wap<tm1(cre)Arge>/Wap<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537
• whey acidic protein
  http://metadb.riken.jp/db/mgi_rdf/MGI:98943
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm3Tyj>/Trp53<+>,Wap<tm1(cre)Arge>/Wap<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm3Tyj>|Wap<tm1(cre)Arge>|Brca1<tm2.1Cxd>|Wap<+>|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor latency
  http://purl.obolibrary.org/obo/MP_0010308

文献

http://purl.org/net/cito/citesAsAuthority

• Reena. Shakya, et.al., BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity., Science (New York, N.Y.), 2011, 334
  http://rdf.ncbi.nlm.nih.gov/pubmed/22034435