decreased tumor latency_Brca1<tm1Thl>/Brca1<tm1Thl>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Thl>/Trp53<tm1Thl>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0010308I129S4SvJaeC57BL6FVBNBrca1tm1ThlBrca1tm1ThlKrastm4TyjKrasTrp53tm1ThlTrp53tm1ThlTgPdx1cre6Tuv0Trp53tm1ThlBrca1tm1ThlKrastm4TyjTgPdx1cre6TuvKras

decreased tumor latency_Brca1<tm1Thl>/Brca1<tm1Thl>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Thl>/Trp53<tm1Thl>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm1Thl>/Brca1<tm1Thl>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Thl>/Trp53<tm1Thl>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Thl>|Brca1<tm1Thl>|Kras<tm4Tyj>|Tg(Pdx1-cre)6Tuv|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor latency
  http://purl.obolibrary.org/obo/MP_0010308

文献

http://purl.org/net/cito/citesAsAuthority

• Reena. Shakya, et.al., BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity., Science (New York, N.Y.), 2011, 334
  http://rdf.ncbi.nlm.nih.gov/pubmed/22034435