increased acute lymphoblastic leukemia incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0010336I129P2OlaHsd129S4SvJaeC57BL6CBAPtentm1HwuPtentm1HwuRps6kb1tm1GthoRps6kb1tm1GthoTgMx1cre1Cgn0TgMx1cre1CgnRps6kb1tm1GthoPtentm1Hwu

increased acute lymphoblastic leukemia incidence_Pten<tm1Hwu>/Pten<tm1Hwu>,Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• ribosomal protein S6 kinase, polypeptide 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1270849
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm1Hwu>/Pten<tm1Hwu>,Rps6kb1<tm1Gtho>/Rps6kb1<tm1Gtho>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Mx1-cre)1Cgn|Rps6kb1<tm1Gtho>|Pten<tm1Hwu>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased acute lymphoblastic leukemia incidence
  http://purl.obolibrary.org/obo/MP_0010336

文献

http://purl.org/net/cito/citesAsAuthority

• Preeti. Tandon, et.al., Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21262837