postnatal lethality, complete penetrance_Sirt1<tm1.1Cxd>/Sirt1<tm1.1Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>

http://metadb.riken.jp/0011085EI129S6SvEvTac129S7SvEvBrdBlackSwissFVBNorI129S6SvEvTac129S7SvEvBrdC57BL6FVBNSirt1tm11CxdSirt1tm11CxdTrp53tm1BrdTrp53tm1BrdSirt1tm11CxdTrp53tm1Brd

postnatal lethality, complete penetrance_Sirt1<tm1.1Cxd>/Sirt1<tm1.1Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• sirtuin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2135607

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Sirt1<tm1.1Cxd>/Sirt1<tm1.1Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sirt1<tm1.1Cxd>|Trp53<tm1Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete postnatal lethality
  http://purl.obolibrary.org/obo/MP_0011085

文献

http://purl.org/net/cito/citesAsAuthority

• Rui-Hong. Wang, et.al., Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice., Cancer cell, 2008, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/18835033