postnatal lethality, complete penetrance_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(ACTA1-SMN)63Ahmb/0,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>

http://metadb.riken.jp/0011085I129P2OlaHsdFVBNSmn1tm1MsdSmn1tm1MsdTgACTA1SMN63Ahmb0Grm7TgSMN289AhmbGrm7TgSMN289AhmbTgACTA1SMN63AhmbSmn1tm1MsdGrm7TgSMN289Ahmb

postnatal lethality, complete penetrance_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(ACTA1-SMN)63Ahmb/0,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 63, Arthur H M Burghes
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774932
• survival motor neuron 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109257
• glutamate receptor, metabotropic 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:1351344

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(ACTA1-SMN)63Ahmb/0,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(ACTA1-SMN)63Ahmb|Smn1<tm1Msd>|Grm7<Tg(SMN2)89Ahmb>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete postnatal lethality
  http://purl.obolibrary.org/obo/MP_0011085

文献

http://purl.org/net/cito/citesAsAuthority

• Tatiana O. Gavrilina, et.al., Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect., Human molecular genetics, 2008, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/18178576