embryonic lethality, complete penetrance_Brca1<tm1Arge>/Brca1<tm1Arge>,Tg(Hsp70-1-cre)1Arge/0

http://metadb.riken.jp/0011092I129SSvEvC57BL6JCBABrca1tm1ArgeBrca1tm1ArgeTgHsp701cre1Arge0TgHsp701cre1ArgeBrca1tm1Arge

embryonic lethality, complete penetrance_Brca1<tm1Arge>/Brca1<tm1Arge>,Tg(Hsp70-1-cre)1Arge/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Argiris Efstratiadis
  http://metadb.riken.jp/db/mgi_rdf/MGI:2447235
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm1Arge>/Brca1<tm1Arge>,Tg(Hsp70-1-cre)1Arge/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Hsp70-1-cre)1Arge|Brca1<tm1Arge>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * C57BL/6J * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete embryonic lethality
  http://purl.obolibrary.org/obo/MP_0011092

文献

http://purl.org/net/cito/citesAsAuthority

• Reena. Shakya, et.al., The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/18443292