embryonic lethality during organogenesis, complete penetrance_Cacnb2<tm1Mfre>/Cacnb2<tm1.1Mfre>,Myl2<tm1(cre)Krc>/Myl2<+>

http://metadb.riken.jp/0011098I129S1Sv129S4SvJae129X1SvJC57BL6NFVBNCacnb2tm1MfreCacnb2tm11MfreMyl2tm1creKrcMyl2Cacnb2tm1MfreCacnb2tm11MfreMyl2tm1creKrcMyl2

embryonic lethality during organogenesis, complete penetrance_Cacnb2<tm1Mfre>/Cacnb2<tm1.1Mfre>,Myl2<tm1(cre)Krc>/Myl2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• myosin, light polypeptide 2, regulatory, cardiac, slow
  http://metadb.riken.jp/db/mgi_rdf/MGI:97272
• calcium channel, voltage-dependent, beta 2 subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:894644

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cacnb2<tm1Mfre>/Cacnb2<tm1.1Mfre>,Myl2<tm1(cre)Krc>/Myl2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cacnb2<tm1Mfre>|Cacnb2<tm1.1Mfre>|Myl2<tm1(cre)Krc>|Myl2<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete embryonic lethality during organogenesis
  http://purl.obolibrary.org/obo/MP_0011098

文献

http://purl.org/net/cito/citesAsAuthority

• Petra. Weissgerber, et.al., Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation., Circulation research, 2006, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/16946137