embryonic lethality during organogenesis, complete penetrance_Hcn4<tm1Jsr>/Hcn4<tm1Jsr>,Myl2<tm1(cre)Krc>/Myl2<+>

http://metadb.riken.jp/0011098I129SvHcn4tm1JsrHcn4tm1JsrMyl2tm1creKrcMyl2Hcn4tm1JsrMyl2Myl2tm1creKrc

embryonic lethality during organogenesis, complete penetrance_Hcn4<tm1Jsr>/Hcn4<tm1Jsr>,Myl2<tm1(cre)Krc>/Myl2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• myosin, light polypeptide 2, regulatory, cardiac, slow
  http://metadb.riken.jp/db/mgi_rdf/MGI:97272
• hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1298209

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hcn4<tm1Jsr>/Hcn4<tm1Jsr>,Myl2<tm1(cre)Krc>/Myl2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Hcn4<tm1Jsr>|Myl2<+>|Myl2<tm1(cre)Krc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete embryonic lethality during organogenesis
  http://purl.obolibrary.org/obo/MP_0011098

文献

http://purl.org/net/cito/citesAsAuthority

• Juliane. Stieber, et.al., The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart., Proceedings of the National Academy of Sciences of the United States of America, 2003, 100
  http://rdf.ncbi.nlm.nih.gov/pubmed/14657344