preweaning lethality, complete penetrance_Mdm4<tm1Glo>/Mdm4<tm1Glo>,Trp53<tm1Adv>/Trp53<tm1Adv>

http://metadb.riken.jp/0011100I129S4SvJaeMdm4tm1GloMdm4tm1GloTrp53tm1AdvTrp53tm1AdvMdm4tm1GloTrp53tm1Adv

preweaning lethality, complete penetrance_Mdm4<tm1Glo>/Mdm4<tm1Glo>,Trp53<tm1Adv>/Trp53<tm1Adv>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transformed mouse 3T3 cell double minute 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:107934

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mdm4<tm1Glo>/Mdm4<tm1Glo>,Trp53<tm1Adv>/Trp53<tm1Adv>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mdm4<tm1Glo>|Trp53<tm1Adv>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete preweaning lethality
  http://purl.obolibrary.org/obo/MP_0011100

文献

http://purl.org/net/cito/citesAsAuthority

• Tomoo. Iwakuma, et.al., Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice., Oncogene, 2004, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/15361844