prenatal lethality, incomplete penetrance_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>

http://metadb.riken.jp/0011101I129S2SvPasC57BL6JTgACTBNOTCH11Shn0TgNescre1Kln0Trp53tm1TyjTrp53tm1TyjTgNescre1KlnTgACTBNOTCH11ShnTrp53tm1Tyj

prenatal lethality, incomplete penetrance_Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Rudiger Klein
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176172
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Jie Shen
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044587

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53<tm1Tyj>/Trp53<tm1Tyj>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Nes-cre)1Kln|Tg(ACTB-NOTCH1)1Shn|Trp53<tm1Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• partial prenatal lethality
  http://purl.obolibrary.org/obo/MP_0011101

文献

http://purl.org/net/cito/citesAsAuthority

• Xudong. Yang, et.al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway., Developmental biology, 2004, 269
  http://rdf.ncbi.nlm.nih.gov/pubmed/15081359