embryonic lethality, incomplete penetrance_Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?

http://metadb.riken.jp/0011102I129C57BL6CBAFzd4tm1NatFzd4Igs1tm2CAGBgeoNdpEGFPNatIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcIgs1tm2CAGBgeoNdpEGFPNatTgSox2cre1AmcFzd4tm1NatFzd4

embryonic lethality, incomplete penetrance_Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• intergenic site 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:5319510
• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:2656537
• frizzled class receptor 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:108520

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Fzd4<tm1Nat>/Fzd4<+>,Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>/Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>,Tg(Sox2-cre)1Amc/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Igs1<tm2(CAG-Bgeo,-Ndp,-EGFP)Nat>|Tg(Sox2-cre)1Amc|Fzd4<tm1Nat>|Fzd4<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• partial embryonic lethality
  http://purl.obolibrary.org/obo/MP_0011102

文献

http://purl.org/net/cito/citesAsAuthority

• Xin. Ye, et.al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization., Cell, 2009, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/19837032