lethality during fetal growth through weaning, incomplete penetrance_Hic2<Gt(E225A08)1.1Wrst>/Hic2<Gt(E225A08)1.1Wrst>,Mesp1<tm2(cre)Ysa>/Mesp1<+>

http://metadb.riken.jp/0011112I129P2OlaHsdC57BL6NCrljCBAJNCrljHic2GtE225A0811WrstHic2GtE225A0811WrstMesp1tm2creYsaMesp1Mesp1Hic2GtE225A0811WrstMesp1tm2creYsa

lethality during fetal growth through weaning, incomplete penetrance_Hic2<Gt(E225A08)1.1Wrst>/Hic2<Gt(E225A08)1.1Wrst>,Mesp1<tm2(cre)Ysa>/Mesp1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• mesoderm posterior 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:107785
• hypermethylated in cancer 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1929869

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hic2<Gt(E225A08)1.1Wrst>/Hic2<Gt(E225A08)1.1Wrst>,Mesp1<tm2(cre)Ysa>/Mesp1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mesp1<+>|Hic2<Gt(E225A08)1.1Wrst>|Mesp1<tm2(cre)Ysa>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• partial lethality during fetal growth through weaning
  http://purl.obolibrary.org/obo/MP_0011112

文献

http://purl.org/net/cito/citesAsAuthority

• Iain M. Dykes, et.al., HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region., Circulation research, 2014, 115
  http://rdf.ncbi.nlm.nih.gov/pubmed/24748541