abnormal spleen mesenchyme morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Pbx1<tm1Koss>/Pbx1<tm1Koss>,Nkx2-5<tm2(cre)Rph>/Nkx2-5<+>

http://metadb.riken.jp/0011263I129P2OlaHsd129S1SvCdkn2btm1BbdCdkn2btm1BbdPbx1tm1KossPbx1tm1KossNkx25tm2creRphNkx25Nkx25Cdkn2btm1BbdNkx25tm2creRphPbx1tm1Koss

abnormal spleen mesenchyme morphology_Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Pbx1<tm1Koss>/Pbx1<tm1Koss>,Nkx2-5<tm2(cre)Rph>/Nkx2-5<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  http://metadb.riken.jp/db/mgi_rdf/MGI:104737
• pre B cell leukemia homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97495
• NK2 homeobox 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:97350

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2b<tm1Bbd>/Cdkn2b<tm1Bbd>,Pbx1<tm1Koss>/Pbx1<tm1Koss>,Nkx2-5<tm2(cre)Rph>/Nkx2-5<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nkx2-5<+>|Cdkn2b<tm1Bbd>|Nkx2-5<tm2(cre)Rph>|Pbx1<tm1Koss>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal spleen mesenchyme morphology
  http://purl.obolibrary.org/obo/MP_0011263

文献

http://purl.org/net/cito/citesAsAuthority

• Matthew. Koss, et.al., Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module., Developmental cell, 2012, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/22560297