renal glomerulus fibrosis_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(NPHS2-cre)295Lbh/?

http://metadb.riken.jp/0011377I129S4SvJaeC57BL6SJLVhltm1JaeVhltm1JaeTgNPHS2cre295LbhVhltm1JaeTgNPHS2cre295Lbh

renal glomerulus fibrosis_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(NPHS2-cre)295Lbh/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• von Hippel-Lindau tumor suppressor
  http://metadb.riken.jp/db/mgi_rdf/MGI:103223
• transgene insertion 295, Lawrence B Holzman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450360

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(NPHS2-cre)295Lbh/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Vhl<tm1Jae>|Tg(NPHS2-cre)295Lbh

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• renal glomerulus fibrosis
  http://purl.obolibrary.org/obo/MP_0011377

文献

http://purl.org/net/cito/citesAsAuthority

• Brooke M. Steenhard, et.al., Deletion of von Hippel-Lindau in glomerular podocytes results in glomerular basement membrane thickening, ectopic subepithelial deposition of collagen {alpha}1{alpha}2{alpha}1(IV), expression of neuroglobin, and proteinuria., The American journal of pathology, 2010, 177
  http://rdf.ncbi.nlm.nih.gov/pubmed/20522651