decreased fibroblast proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm3Wahl>/Trp53<tm3Wahl>

http://metadb.riken.jp/0011704I129S4SvJae129S5SvEvBrdMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm3WahlTrp53tm3WahlTrp53tm3WahlMdm4GtVICTR207Lex

decreased fibroblast proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm3Wahl>/Trp53<tm3Wahl>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformed mouse 3T3 cell double minute 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:107934
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm3Wahl>/Trp53<tm3Wahl>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm3Wahl>|Mdm4<Gt(VICTR20)7Lex>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S5/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased fibroblast proliferation
  http://purl.obolibrary.org/obo/MP_0011704

文献

http://purl.org/net/cito/citesAsAuthority

• Franck. Toledo, et.al., A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network., Cancer cell, 2006, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/16616333