increased granulosa cell tumor incidence_Foxo1<tm1Rdp>/Foxo1<tm1.1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1.1Rdp>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0

http://metadb.riken.jp/0012411I129S4SvJae129S6SvEvTacFoxo1tm1RdpFoxo1tm11RdpFoxo3tm1RdpFoxo3tm11RdpPtentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Foxo1tm11RdpPtentm1HwuFoxo3tm11RdpTgCYP19A1cre1JriFoxo3tm1RdpFoxo1tm1Rdp

increased granulosa cell tumor incidence_Foxo1<tm1Rdp>/Foxo1<tm1.1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1.1Rdp>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• forkhead box O1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890077
• forkhead box O3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890081
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transgene insertion 1, JoAnne Richards
  http://metadb.riken.jp/db/mgi_rdf/MGI:3799680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Foxo1<tm1Rdp>/Foxo1<tm1.1Rdp>,Foxo3<tm1Rdp>/Foxo3<tm1.1Rdp>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Foxo1<tm1.1Rdp>|Pten<tm1Hwu>|Foxo3<tm1.1Rdp>|Tg(CYP19A1-cre)1Jri|Foxo3<tm1Rdp>|Foxo1<tm1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S6/SvEvTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased granulosa cell tumor incidence
  http://purl.obolibrary.org/obo/MP_0012411

文献

http://purl.org/net/cito/citesAsAuthority

• Zhilin. Liu, et.al., FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development., Molecular endocrinology (Baltimore, Md.), 2015, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/26061565