embryonic lethality prior to tooth bud stage_Cflar<tm1Ywh>/Cflar<tm1Ywh>,Gt(ROSA)26Sor<tm16(cre)Arte>/Gt(ROSA)26Sor<+>,Ripk3<tm2Vmd>/Ripk3<tm2Vmd>

http://metadb.riken.jp/0013293I129S6SvEvTacC57BL6NC57BL6NTacCflartm1YwhCflartm1YwhGtROSA26Sortm16creArteGtROSA26SorRipk3tm2VmdRipk3tm2VmdRipk3tm2VmdGtROSA26SorCflartm1YwhGtROSA26Sortm16creArte

embryonic lethality prior to tooth bud stage_Cflar<tm1Ywh>/Cflar<tm1Ywh>,Gt(ROSA)26Sor<tm16(cre)Arte>/Gt(ROSA)26Sor<+>,Ripk3<tm2Vmd>/Ripk3<tm2Vmd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• receptor-interacting serine-threonine kinase 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:2154952
• CASP8 and FADD-like apoptosis regulator
  http://metadb.riken.jp/db/mgi_rdf/MGI:1336166
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cflar<tm1Ywh>/Cflar<tm1Ywh>,Gt(ROSA)26Sor<tm16(cre)Arte>/Gt(ROSA)26Sor<+>,Ripk3<tm2Vmd>/Ripk3<tm2Vmd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ripk3<tm2Vmd>|Gt(ROSA)26Sor<+>|Cflar<tm1Ywh>|Gt(ROSA)26Sor<tm16(cre)Arte>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• embryonic lethality prior to tooth bud stage
  http://purl.obolibrary.org/obo/MP_0013293

文献

http://purl.org/net/cito/citesAsAuthority

• Kim. Newton, et.al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis., Science (New York, N.Y.), 2014, 343
  http://rdf.ncbi.nlm.nih.gov/pubmed/24557836