J. Liu, et.al., Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity., The Journal of pharmacology and experimental therapeutics, 1999, 289

http://rdf.ncbi.nlm.nih.gov/pubmed/10087053

J. Liu, et.al., Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity., The Journal of pharmacology and experimental therapeutics, 1999, 289

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal lipid homeostasis_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0002118I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• increased incidence of tumors by chemical induction_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0004499I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• abnormal lipid homeostasis_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0002118I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri
• increased sensitivity to xenobiotic induced morbidity/mortality_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0009766I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• increased circulating alanine transaminase level_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0002941I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri
• hepatic necrosis_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0001654I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• increased physiological sensitivity to xenobiotic_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0008873I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• increased physiological sensitivity to xenobiotic_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0008873I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri
• hepatic necrosis_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0001654I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri
• increased sensitivity to xenobiotic induced morbidity/mortality_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0009766I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri
• increased circulating alanine transaminase level_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0002941I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• abnormal hepatocyte morphology_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>
  http://metadb.riken.jp/0000607I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch
• abnormal hepatocyte morphology_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>
  http://metadb.riken.jp/0000607I129S7SvEvBrdMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri