C K. Qu, et.al., Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96

http://rdf.ncbi.nlm.nih.gov/pubmed/10411909

C K. Qu, et.al., Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• epidermal atrophy_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001221I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal lung development_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001176I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal hair growth_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0002073I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• flaky skin_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001195I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal hair follicle orientation_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0000383I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal hair follicle development_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0003704I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• thin skin_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001199I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal intestine morphology_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0000477I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• atelectasis_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001177I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• dry skin_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0003853I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• postnatal lethality, incomplete penetrance_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0011086I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• decreased hair follicle number_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0000379I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal breathing pattern_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001951I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• thick pulmonary interalveolar septum_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001179I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• eyelids open at birth_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001302I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• cachexia_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0005150I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal skin condition_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001191I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• waved hair_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0000410I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal muscle morphology_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0002108I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• decreased subcutaneous adipose tissue amount_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0008844I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• postnatal growth retardation_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001732I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• thin epidermis_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0001218I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• abnormal hair follicle morphology_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0000377I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2
• intestinal hypoperistalsis_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Paw>/Ptpn11<+>
  http://metadb.riken.jp/0003290I129S1Sv129X1SvJB6EiC3SnaAEgfrwa2Wnt3avtC57BL6Egfrwa2Egfrwa2Ptpn11tm1PawPtpn11Ptpn11tm1PawPtpn11Egfrwa2