J. Song, et.al., The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice., Developmental biology, 1999, 213

http://rdf.ncbi.nlm.nih.gov/pubmed/10452853

J. Song, et.al., The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice., Developmental biology, 1999, 213

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Acvr2a<tm1Hsch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179547

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic-extraembryonic boundary constriction_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0012135I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• abnormal rostral-caudal axis patterning_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0005221I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• increased embryonic epiblast cell apoptosis_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0011191I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1Hsch
• embryonic lethality during organogenesis, incomplete penetrance_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>
  http://metadb.riken.jp/0011108I129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2atm1Hsch
• absent head fold_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0012724I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• cyclopia_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0005163I129SSvEv129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschNodaltm1RobNodalAcvr2atm1HschNodaltm1RobNodal
• absent heart tube_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0012081I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• perinatal lethality, complete penetrance_Acvr2a<tm1Hsch>/Acvr2a<+>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0011089I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2aAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1HschAcvr2aAcvr2btm1Enl
• cyclopia_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>
  http://metadb.riken.jp/0005163I129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2atm1Hsch
• abnormal gastrulation_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0001695I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• embryonic-extraembryonic boundary constriction_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0012135I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1Hsch
• embryonic growth arrest_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0001730I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1Hsch
• abnormal gastrulation_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0001695I129SSvEv129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschNodaltm1RobNodalAcvr2atm1HschNodaltm1RobNodal
• embryonic lethality, complete penetrance_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0011092I129SSvEv129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschNodaltm1RobNodalAcvr2atm1HschNodaltm1RobNodal
• abnormal head morphology_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0000432I129SSvEv129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschNodaltm1RobNodalAcvr2atm1HschNodaltm1RobNodal
• abnormal primitive streak elongation_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0012685I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• decreased forebrain size_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Nodal<tm1Rob>/Nodal<+>
  http://metadb.riken.jp/0012138I129SSvEv129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschNodaltm1RobNodalAcvr2atm1HschNodaltm1RobNodal
• abnormal mesoderm development_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0001680I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• embryonic lethality between implantation and somite formation, complete penetrance_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0011096I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• embryonic growth arrest_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0001730I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• abnormal gastrulation_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>
  http://metadb.riken.jp/0001695I129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2atm1Hsch
• embryonic lethality between implantation and somite formation, complete penetrance_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0011096I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1Hsch
• absent mesoderm_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0001683I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1Hsch
• absent amnion_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0005030I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• failure to gastrulate_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<tm1Enl>
  http://metadb.riken.jp/0001696I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2btm1EnlAcvr2btm1EnlAcvr2atm1Hsch
• absent allantois_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>,Acvr2b<tm1Enl>/Acvr2b<+>
  http://metadb.riken.jp/0003087I129S1Sv129S4SvJaeC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2btm1EnlAcvr2bAcvr2btm1EnlAcvr2bAcvr2atm1Hsch
• mandible hypoplasia_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>
  http://metadb.riken.jp/0000460I129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2atm1Hsch
• abnormal testis development_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>
  http://metadb.riken.jp/0003830I129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2atm1Hsch
• reduced female fertility_Acvr2a<tm1Hsch>/Acvr2a<tm1Hsch>
  http://metadb.riken.jp/0001923I129S1SvC57BL6JAcvr2atm1HschAcvr2atm1HschAcvr2atm1Hsch

class

http://purl.org/net/cito/citesAsAuthority

• Acvr2a<tm1Hsch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179547