B. Chen, et.al., Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis., Nature genetics, 2000, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/10700187

B. Chen, et.al., Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis., Nature genetics, 2000, 24

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• prolonged RR interval_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0010506I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• perinatal lethality, incomplete penetrance_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0011090I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• congestive heart failure_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0006138I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• prolonged PR interval_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0003896I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• thick pulmonary valve_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0010601I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• prolonged PR interval_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0003896STOCKEgfrwa2Egfrwa2Egfrwa2Egfrwa2
• increased left ventricle diastolic pressure_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0003819I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• abnormal aortic valve morphology_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0002747STOCKEgfrwa2Egfrwa2Egfrwa2Egfrwa2
• aortic valve stenosis_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0006117I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• increased left ventricle systolic pressure_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0003820I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• eyelids open at birth_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0001302I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• cardiac hypertrophy_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0001625I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• thick aortic valve_Egfr<tm1Mag>/Egfr<wa2>
  http://metadb.riken.jp/0010594I129S2SvPasB6EiC3SnaAEgfrwa2Wnt3avtCD1Egfrtm1MagEgfrwa2Egfrwa2Egfrtm1Mag
• thick aortic valve_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0010594B6EiC3SnaAEgfrwa2Wnt3avtJEgfrwa2Egfrwa2Egfrwa2
• abnormal semilunar valve morphology_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0002746I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• prolonged ST segment_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0010570I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• aortic valve regurgitation_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0006047STOCKEgfrwa2Egfrwa2Egfrwa2Egfrwa2
• prolonged QRS complex duration_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0010392I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• prolonged QT interval_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0003233I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• aortic valve regurgitation_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0006047I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• increased left ventricle systolic pressure_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0003820STOCKEgfrwa2Egfrwa2Egfrwa2Egfrwa2
• increased systemic arterial blood pressure_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0002842I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• thick aortic valve_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0010594I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• abnormal impulse conducting system conduction_Egfr<wa2>/Egfr<wa2>,Ptpn11<tm1Rbn>/Ptpn11<+>
  http://metadb.riken.jp/0003137I129B6EiC3SnaAEgfrwa2Wnt3avtEgfrwa2Egfrwa2Ptpn11tm1RbnPtpn11Egfrwa2Ptpn11Ptpn11tm1Rbn
• abnormal semilunar valve morphology_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0002746STOCKEgfrwa2Egfrwa2Egfrwa2Egfrwa2
• prolonged RR interval_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0010506STOCKEgfrwa2Egfrwa2Egfrwa2Egfrwa2
• enlarged aortic valve_Egfr<wa2>/Egfr<wa2>
  http://metadb.riken.jp/0010591B6EiC3SnaAEgfrwa2Wnt3avtJEgfrwa2Egfrwa2Egfrwa2