N. Ogata, et.al., Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover., The Journal of clinical investigation, 2000, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/10749573

N. Ogata, et.al., Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover., The Journal of clinical investigation, 2000, 105

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating insulin level_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0002079IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• decreased compact bone thickness_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0000135IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• decreased chondrocyte number_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0000167IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• decreased long bone epiphyseal plate size_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0006396IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• decreased osteoblast cell number_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0004989IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• abnormal trabecular bone morphology_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0000130IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• short tibia_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0002764IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• decreased bone mineral density_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0000063IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• abnormal osteoclast differentiation_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0008396IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• short femur_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0003109IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• abnormal osteoclast physiology_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0001541IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka
• abnormal osteoblast physiology_Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0005006IC57BL6CBAIrs1tm1TkaIrs1tm1TkaIrs1tm1Tka