J. Lewis, et.al., Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein., Nature genetics, 2000, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/10932182

J. Lewis, et.al., Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein., Nature genetics, 2000, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-MAPT)4Hlmc
  http://metadb.riken.jp/db/mgi_rdf/MGI:3604149
• Tg(Prnp-MAPT*P301L)JNPL3Hlmc
  http://metadb.riken.jp/db/mgi_rdf/MGI:3604148
• Tg(Prnp-MAPT)25Hlmc
  http://metadb.riken.jp/db/mgi_rdf/MGI:3604150

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased grip strength_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0010053IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• gliosis_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0002183IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• neurofibrillary tangles_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0003214IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• abnormal posture_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001504IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• abnormal locomotor behavior_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001392IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• premature death_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0002083IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• weight loss_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001263IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• decreased motor neuron number_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0000939IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• eye inflammation_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001851IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• abnormal cranial nerve morphology_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001056IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• decreased vocalization_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0020351IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• abnormal sarcomere morphology_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0004090IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• limb grasping_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001513IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• abnormal skeletal muscle fiber morphology_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0003084IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• decreased grooming behavior_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0001442IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• cachexia_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0005150IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc
• abnormal brain morphology_Tg(Prnp-MAPT)25Hlmc/0
  http://metadb.riken.jp/0002152IC57BL6DBA2TgPrnpMAPT25Hlmc0TgPrnpMAPT25Hlmc
• weakness_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
  http://metadb.riken.jp/0000746IC57BL6DBA2TgPrnpMAPTP301LJNPL3HlmcTgPrnpMAPTP301LJNPL3Hlmc

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-MAPT)4Hlmc
  http://metadb.riken.jp/db/mgi_rdf/MGI:3604149
• Tg(Prnp-MAPT*P301L)JNPL3Hlmc
  http://metadb.riken.jp/db/mgi_rdf/MGI:3604148
• Tg(Prnp-MAPT)25Hlmc
  http://metadb.riken.jp/db/mgi_rdf/MGI:3604150