H. Du, et.al., Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span., Journal of lipid research, 2001, 42

http://rdf.ncbi.nlm.nih.gov/pubmed/11290820

H. Du, et.al., Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span., Journal of lipid research, 2001, 42

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal interscapular fat pad morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0006320I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• decreased brown adipose tissue amount_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0001780I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal brown adipose tissue morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0002971I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• pale kidney_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0004969I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased spleen weight_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0004952I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• premature death_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0002083I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal inguinal fat pad morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0005336I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal lipid level_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0001547I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• decreased epididymal fat pad weight_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0009289I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal Kupffer cell morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0008114I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal spleen morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000689I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• enlarged spleen_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000691I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• hepatic steatosis_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0002628I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal small intestine morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000496I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal retroperitoneal fat pad morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0005337I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal choroid plexus morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000820I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• decreased circulating HDL cholesterol level_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000186I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal hepatocyte morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000607I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal small intestinal villus morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0008108I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal white fat cell size_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0009132I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal jejunum morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0004002I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased circulating LDL cholesterol level_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000182I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• enlarged mesenteric lymph nodes_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0008466I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• decreased subcutaneous adipose tissue amount_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0008844I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased brown fat cell lipid droplet size_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0009124I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• enlarged liver_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0000599I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased liver weight_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0002981I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• insulin resistance_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0005331I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal duodenum morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0003271I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased circulating insulin level_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0002079I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• abnormal lung morphology_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0001175I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased circulating free fatty acid level_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0001554I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• decreased white adipose tissue amount_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0001783I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• absent subcutaneous adipose tissue_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0008843I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb
• increased food intake_Lipa<tm1Ggb>/Lipa<tm1Ggb>
  http://metadb.riken.jp/0011939I129P2OlaHsdCF1Lipatm1GgbLipatm1GgbLipatm1Ggb

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD19905
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19905