J. Perea, et.al., Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A., Human molecular genetics, 2001, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/11331611

J. Perea, et.al., Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A., Human molecular genetics, 2001, 10

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO/CMV-Pmp22)JP18Clh
  http://metadb.riken.jp/db/mgi_rdf/MGI:5779548
• Tg(PMP22-tTA)JY13Clh
  http://metadb.riken.jp/db/mgi_rdf/MGI:5779547

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO/CMV-Pmp22)JP18Clh
  http://metadb.riken.jp/db/mgi_rdf/MGI:5779548
• Tg(PMP22-tTA)JY13Clh
  http://metadb.riken.jp/db/mgi_rdf/MGI:5779547

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased nerve conduction velocity_Tg(PMP22-tTA)JY13Clh/0,Tg(tetO/CMV-Pmp22)JP18Clh/0
  http://metadb.riken.jp/0008814IC57BL6JCBACaTgPMP22tTAJY13Clh0TgtetOCMVPmp22JP18Clh0TgtetOCMVPmp22JP18ClhTgPMP22tTAJY13Clh
• demyelination_Tg(PMP22-tTA)JY13Clh/0,Tg(tetO/CMV-Pmp22)JP18Clh/0
  http://metadb.riken.jp/0000921IC57BL6JCBACaTgPMP22tTAJY13Clh0TgtetOCMVPmp22JP18Clh0TgtetOCMVPmp22JP18ClhTgPMP22tTAJY13Clh
• decreased myelin sheath thickness_Tg(PMP22-tTA)JY13Clh/0,Tg(tetO/CMV-Pmp22)JP18Clh/0
  http://metadb.riken.jp/0011731IC57BL6JCBACaTgPMP22tTAJY13Clh0TgtetOCMVPmp22JP18Clh0TgtetOCMVPmp22JP18ClhTgPMP22tTAJY13Clh
• abnormal gait_Tg(PMP22-tTA)JY13Clh/0,Tg(tetO/CMV-Pmp22)JP18Clh/0
  http://metadb.riken.jp/0001406IC57BL6JCBACaTgPMP22tTAJY13Clh0TgtetOCMVPmp22JP18Clh0TgtetOCMVPmp22JP18ClhTgPMP22tTAJY13Clh
• increased Schwann cell number_Tg(PMP22-tTA)JY13Clh/0,Tg(tetO/CMV-Pmp22)JP18Clh/0
  http://metadb.riken.jp/0010742IC57BL6JCBACaTgPMP22tTAJY13Clh0TgtetOCMVPmp22JP18Clh0TgtetOCMVPmp22JP18ClhTgPMP22tTAJY13Clh
• abnormal myelination_Tg(PMP22-tTA)JY13Clh/0,Tg(tetO/CMV-Pmp22)JP18Clh/0
  http://metadb.riken.jp/0000920IC57BL6JCBACaTgPMP22tTAJY13Clh0TgtetOCMVPmp22JP18Clh0TgtetOCMVPmp22JP18ClhTgPMP22tTAJY13Clh