J D. Gorham, et.al., Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis., Journal of immunology (Baltimore, Md. : 1950), 2001, 166

http://rdf.ncbi.nlm.nih.gov/pubmed/11342667

J D. Gorham, et.al., Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis., Journal of immunology (Baltimore, Md. : 1950), 2001, 166

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating alanine transaminase level_Il4<tm2Nnt>/Il4<tm2Nnt>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0002941CCgTgfb1tm1DoeIl4tm2NntIl4tm2NntIl4tm2NntTgfb1tm1DoeTgfb1tm1DoeIl4tm2NntTgfb1tm1Doe
• premature death_Ifng<tm1Ts>/Ifng<tm1Ts>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0002083C129Ifngtm1TsTgfb1tm1DoeIfngtm1TsIfngtm1TsTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeIfngtm1Ts
• prenatal lethality, incomplete penetrance_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0011101I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• decreased CD4-positive, alpha beta T cell number_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0008075C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• increased circulating alanine transaminase level_Ifng<tm1Ts>/Ifng<tm1Ts>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0002941C129Ifngtm1TsTgfb1tm1DoeIfngtm1TsIfngtm1TsTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeIfngtm1Ts
• lung inflammation_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001861I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• increased interferon-gamma secretion_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0008566I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• heart inflammation_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001853I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• prenatal lethality, incomplete penetrance_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0011101C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• liver inflammation_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001860I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• increased interferon-gamma secretion_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0008566C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• postnatal lethality, complete penetrance_Il4<tm2Nnt>/Il4<tm2Nnt>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0011085CCgTgfb1tm1DoeIl4tm2NntIl4tm2NntIl4tm2NntTgfb1tm1DoeTgfb1tm1DoeIl4tm2NntTgfb1tm1Doe
• liver inflammation_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001860C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• hepatic necrosis_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001654C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• postnatal lethality, incomplete penetrance_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0011086C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• liver inflammation_Il4<tm2Nnt>/Il4<tm2Nnt>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001860CCgTgfb1tm1DoeIl4tm2NntIl4tm2NntIl4tm2NntTgfb1tm1DoeTgfb1tm1DoeIl4tm2NntTgfb1tm1Doe
• increased circulating alanine transaminase level_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0002941I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• decreased body weight_Ifng<tm1Ts>/Ifng<tm1Ts>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001262C129Ifngtm1TsTgfb1tm1DoeIfngtm1TsIfngtm1TsTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeIfngtm1Ts
• increased T-helper 1 cell number_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0008086C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• heart inflammation_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001853C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• postnatal lethality, complete penetrance_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0011085I129S2SvPasBALBcCF1Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• increased circulating alanine transaminase level_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0002941C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe
• cachexia_Ifng<tm1Ts>/Ifng<tm1Ts>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0005150C129Ifngtm1TsTgfb1tm1DoeIfngtm1TsIfngtm1TsTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeIfngtm1Ts
• liver inflammation_Ifng<tm1Ts>/Ifng<tm1Ts>,Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0001860C129Ifngtm1TsTgfb1tm1DoeIfngtm1TsIfngtm1TsTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeIfngtm1Ts
• increased CD4-positive, alpha beta T cell number_Tgfb1<tm1Doe>/Tgfb1<tm1Doe>
  http://metadb.riken.jp/0008074C129S2Tgfb1tm1DoeTgfb1tm1DoeTgfb1tm1DoeTgfb1tm1Doe