M. Tanaka, et.al., Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx., Molecular and cellular biology, 2001, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/11390666

M. Tanaka, et.al., Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx., Molecular and cellular biology, 2001, 21

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal heart atrium morphology_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0003105I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• decreased cell proliferation_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0000352I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• absent atrioventricular cushions_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<+>
  http://metadb.riken.jp/0000298I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26Nkx25tm1SizNkx26tm1SizNkx26
• abnormal pharynx morphology_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<+>
  http://metadb.riken.jp/0002234I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26Nkx25tm1SizNkx26tm1SizNkx26
• embryonic growth retardation_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0003984I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• abnormal pharyngeal pouch morphology_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0006031I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• absent atrioventricular cushions_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0000298I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• pharynx hypoplasia_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>
  http://metadb.riken.jp/0004555I129S4SvJaeSorC57BL6JNkx25tm1SizNkx25tm1SizNkx25tm1Siz
• embryonic lethality during organogenesis_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<+>
  http://metadb.riken.jp/0006207I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26Nkx25tm1SizNkx26tm1SizNkx26
• abnormal heart atrium morphology_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<+>
  http://metadb.riken.jp/0003105I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26Nkx25tm1SizNkx26tm1SizNkx26
• pericardial effusion_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0005312I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• pharynx hypoplasia_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0004555I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• increased apoptosis_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0006042I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• no abnormal phenotype detected_Nkx2-5<tm1Siz>/Nkx2-5<+>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0002169I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25Nkx26tm1SizNkx26tm1SizNkx25tm1SizNkx26tm1SizNkx25
• embryonic lethality during organogenesis, complete penetrance_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>,Nkx2-6<tm1Siz>/Nkx2-6<tm1Siz>
  http://metadb.riken.jp/0011098I129S1Sv129S4SvJaeSor129X1SvJC57BL6JNkx25tm1SizNkx25tm1SizNkx26tm1SizNkx26tm1SizNkx26tm1SizNkx25tm1Siz
• decreased cell proliferation_Nkx2-5<tm1Siz>/Nkx2-5<tm1Siz>
  http://metadb.riken.jp/0000352I129S4SvJaeSorC57BL6JNkx25tm1SizNkx25tm1SizNkx25tm1Siz