H P. Harding, et.al., Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival., Molecular cell, 2001, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/11430819

H P. Harding, et.al., Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival., Molecular cell, 2001, 7

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased pancreatic alpha cell number_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0009176I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• steatorrhea_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0002791I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• postnatal lethality_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0002082I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• decreased body weight_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0001262I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• hyperglycemia_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0001559I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• abnormal pancreatic beta cell physiology_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0003562I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• impaired glucose tolerance_Eif2ak3<tm1Dron>/Eif2ak3<+>
  http://metadb.riken.jp/0005293E129S6SvEvTacEif2ak3tm1DronorI129S6SvEvTacC57BL6Eif2ak3tm1DronEif2ak3Eif2ak3tm1DronEif2ak3
• postnatal lethality, complete penetrance_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0011085129S6SvEvTacEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• postnatal growth retardation_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0001732I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• decreased pancreatic beta cell number_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0003339I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• exocrine pancreatic insufficiency_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0003335I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• abnormal pancreatic islet morphology_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0005215I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• abnormal exocrine pancreas morphology_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0005220I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• abnormal pancreas physiology_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0002693I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron
• decreased circulating insulin level_Eif2ak3<tm1Dron>/Eif2ak3<tm1Dron>
  http://metadb.riken.jp/0002727I129S6SvEvTacSwissWebsterEif2ak3tm1DronEif2ak3tm1DronEif2ak3tm1Dron