X. Liu, et.al., Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia., Proceedings of the National Academy of Sciences of the United States of America, 2001, 98

http://rdf.ncbi.nlm.nih.gov/pubmed/11481479

X. Liu, et.al., Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia., Proceedings of the National Academy of Sciences of the United States of America, 2001, 98

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-TGFB1*C223S*C225S)1Glk
  http://metadb.riken.jp/db/mgi_rdf/MGI:3815091

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• epidermal hyperplasia_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001222IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• progressive hair loss_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0009004IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• acanthosis_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001874IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• dermal hyperplasia_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0004971IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• dermatitis_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001194IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• decreased hair follicle number_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000379IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• abnormal cell proliferation_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000350IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• decreased cell proliferation_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000352IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• reddish skin_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001190IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• abnormal coat/ hair morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000367IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• abnormal skin morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0002060IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• thick dermal layer_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001245IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• hyperkeratosis_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001242IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• abnormal hair cycle_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000427IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• decreased hair follicle number_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000379IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• abnormal epidermal layer morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001216IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• shiny skin_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001196IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• abnormal dermal layer morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001243IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• decreased cell proliferation_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000352IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• thick dermal layer_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001245IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• perinatal lethality, complete penetrance_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0011089IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• acanthosis_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001874IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• abnormal skin physiology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0005501IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• skin inflammation_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0004947IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• decreased body size_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001265IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• skin inflammation_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0004947IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• dermatitis_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001194IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• abnormal hair follicle morphology_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000377IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• prenatal lethality, complete penetrance_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0011091IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• increased keratinocyte apoptosis_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0009580IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• tight skin_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001198IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• thin epidermis_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001218IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• abnormal hair follicle morphology_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0000377IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• epidermal hyperplasia_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001222IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk
• progressive hair loss_Tg(KRT5-rtTA)1Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0009004IFVBNTgKRT5rtTA1Glk0TgtetOTGFB1C223SC225S1Glk0TgKRT5rtTA1GlkTgtetOTGFB1C223SC225S1Glk
• hyperkeratosis_Tg(KRT5-tTA)1216Glk/0,Tg(tetO-TGFB1*C223S*C225S)1Glk/0
  http://metadb.riken.jp/0001242IFVBNTgKRT5tTA1216Glk0TgtetOTGFB1C223SC225S1Glk0TgtetOTGFB1C223SC225S1GlkTgKRT5tTA1216Glk

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-TGFB1*C223S*C225S)1Glk
  http://metadb.riken.jp/db/mgi_rdf/MGI:3815091