A M. Fernández, et.al., Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes., Genes & development, 2001, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/11485987

A M. Fernández, et.al., Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes., Genes & development, 2001, 15

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Ckm-IGF1R*K1003R)1Dlr
  http://metadb.riken.jp/db/mgi_rdf/MGI:3842765

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Ckm-IGF1R*K1003R)1Dlr
  http://metadb.riken.jp/db/mgi_rdf/MGI:3842765

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating insulin level_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0002079FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• increased circulating triglyceride level_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0001552FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• abnormal response/metabolism to endogenous compounds_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0003638FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• abnormal glucose homeostasis_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0002078FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• increased circulating glucose level_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0005559FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• increased liver triglyceride level_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0009355FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• pancreatic islet hyperplasia_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0005491FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• postnatal growth retardation_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0001732FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• insulin resistance_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0005331FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• impaired glucose tolerance_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0005293FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• decreased muscle cell glucose uptake_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0030022FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• impaired cellular glucose import_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0003926FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• decreased body weight_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0001262FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• increased circulating free fatty acid level_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0001554FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr
• abnormal glycogen homeostasis_Tg(Ckm-IGF1R*K1003R)1Dlr/0
  http://metadb.riken.jp/0005438FVBNTgCkmIGF1RK1003R1DlrTgCkmIGF1RK1003R1Dlr0TgCkmIGF1RK1003R1Dlr