J. Lewis, et.al., Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP., Science (New York, N.Y.), 2001, 293

http://rdf.ncbi.nlm.nih.gov/pubmed/11520987

J. Lewis, et.al., Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP., Science (New York, N.Y.), 2001, 293

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• astrocytosis_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0003354IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• decreased grooming behavior_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0001442IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• amyloid beta deposits_Tg(APPSWE)2576Kha/0
  http://metadb.riken.jp/0003329IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgAPPSWE2576Kha
• hunched posture_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0001505IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• paraparesis_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0009434IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• tau protein deposits_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0004250IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• abnormal eye physiology_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0005253IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• neuron degeneration_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0003224IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• decreased vocalization_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0020351IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• neurofibrillary tangles_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0003214IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• decreased grooming behavior_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0001442IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• amyloid beta deposits_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0003329IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• abnormal eye physiology_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0005253IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• abnormal neuron morphology_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0002882IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• gliosis_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0002183IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• neurofibrillary tangles_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0003214IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• neuron degeneration_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0003224IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• gliosis_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0002183IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha
• tau protein deposits_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0004250IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• decreased vocalization_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0020351IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• abnormal neuron morphology_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0002882IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• paraparesis_Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0009434IC57BL6DBA2SJLSWTgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3Hlmc
• hunched posture_Tg(APPSWE)2576Kha/0,Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
  http://metadb.riken.jp/0001505IC57BL6DBA2SJLSWTgAPPSWE2576Kha0TgPrnpMAPTP301LJNPL3Hlmc0TgPrnpMAPTP301LJNPL3HlmcTgAPPSWE2576Kha