M. Ver Heyen, et.al., Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart., Circulation research, 2001, 89

http://rdf.ncbi.nlm.nih.gov/pubmed/11679415

M. Ver Heyen, et.al., Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart., Circulation research, 2001, 89

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653502

class

http://purl.org/net/cito/citesAsAuthority

• Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653502

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• fatigue_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0002899I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• heart left ventricle hypertrophy_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0002625I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• impaired righting response_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0001523I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• decreased litter size_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0001935I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• ascending aorta hypoplasia_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0010469I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• decreased cardiac muscle contractility_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0005140I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• thick ventricular wall_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0002953I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• cardiac interstitial fibrosis_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0005608I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• abnormal locomotor activation_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0003313I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• abnormal cardiac muscle relaxation_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0004084I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• dilated heart right ventricle_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0002754I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• bradykinesia_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0005156I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• abnormal calcium ion homeostasis_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0004231I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• ventricular septal defect_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0010402I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• decreased body weight_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• prenatal lethality, incomplete penetrance_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0011101I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• cardiac fibrosis_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0003141I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• thin ventricle myocardium compact layer_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0010556I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• atrial septal defect_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0010403I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• abnormal heart shape_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0000277I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• increased heart weight_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0002833I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• aorta coarctation_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0003387I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• cardiac hypertrophy_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0001625I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy
• neonatal lethality, incomplete penetrance_Atp2a2<tm1Fwuy>/Atp2a2<tm1Fwuy>
  http://metadb.riken.jp/0011088I129S1Sv129X1SvJSwissAtp2a2tm1FwuyAtp2a2tm1FwuyAtp2a2tm1Fwuy