S A. Backman, et.al., Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease., Nature genetics, 2001, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/11726926

S A. Backman, et.al., Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease., Nature genetics, 2001, 29

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• gliosis_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0002183I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal cerebellar foliation_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000857I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal cerebellum external granule cell layer morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000872I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• decreased hippocampus pyramidal cell number_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0009971I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• megacephaly_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000434I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal cerebellum morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000849I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• decreased Purkinje cell number_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000880I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• hippocampal neuron degeneration_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000811I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• increased brain size_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0005238I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• increased hamartoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0010306I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal dentate gyrus morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000812I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal cerebellar granule cell morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0004098I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal hippocampus pyramidal cell layer_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0008284I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal hippocampus morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000807I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• hydroencephaly_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0001891I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• premature death_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0002083I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal Purkinje cell morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000877I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• abnormal cerebellar molecular layer_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0000889I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• seizures_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0002064I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• ataxia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0001393I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk
• lethargy_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Gfap-cre)1Sbk/0
  http://metadb.riken.jp/0005202I129P2OlaHsdPtentm2MakPtentm2MakTgGfapcre1Sbk0Ptentm2MakTgGfapcre1Sbk

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hydroencephaly in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020038
• lethargy in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020066
• abnormal Purkinje cell morphology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020029
• gliosis in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020043
• abnormal cerebellar foliation in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020027
• decreased hippocampus pyramidal cell number in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020079
• increased hamartoma incidence in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020081
• abnormal cerebellar molecular layer in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020031
• decreased Purkinje cell number in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020030
• abnormal cerebellum morphology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020026
• megacephaly in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020015
• abnormal hippocampus pyramidal cell layer in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020071
• abnormal dentate gyrus morphology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020025
• abnormal hippocampus morphology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020023
• abnormal cerebellum external granule cell layer morphology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020028
• hippocampal neuron degeneration in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020024
• abnormal cerebellar granule cell morphology in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020059
• premature death in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020041
• increased brain size in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020067
• seizures in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020040
• ataxia in RBRC02300
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020035