Kazuya. Yamagata, et.al., Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes., Diabetes, 2002, 51

http://rdf.ncbi.nlm.nih.gov/pubmed/11756330

Kazuya. Yamagata, et.al., Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes., Diabetes, 2002, 51

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Ins2-TCF1*P291)2Kya
  http://metadb.riken.jp/db/mgi_rdf/MGI:2386579

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Ins2-TCF1*P291)2Kya
  http://metadb.riken.jp/db/mgi_rdf/MGI:2386579

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• small pancreatic islets_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0009172IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• disorganized pancreatic islets_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0009254IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• abnormal pancreatic islet morphology_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0005215IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• abnormal pancreatic beta cell physiology_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0003562IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• decreased pancreatic beta cell proliferation_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0011820IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• decreased pancreatic beta cell number_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0003339IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• hyperglycemia_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0001559IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya
• decreased insulin secretion_Tg(Ins2-TCF1*P291)2Kya/0
  http://metadb.riken.jp/0003059IC57BL6SJLTgIns2TCF1P2912Kya0TgIns2TCF1P2912Kya