Jan. de Boer, et.al., Premature aging in mice deficient in DNA repair and transcription., Science (New York, N.Y.), 2002, 296

http://rdf.ncbi.nlm.nih.gov/pubmed/11950998

Jan. de Boer, et.al., Premature aging in mice deficient in DNA repair and transcription., Science (New York, N.Y.), 2002, 296

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• neonatal lethality, incomplete penetrance_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0011088I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• kyphosis_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000160I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• hyperkeratosis_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001242I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• decreased hematocrit_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0000208I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• kyphosis_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0000160I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• decreased hemoglobin content_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0002874I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• abnormal adipose tissue distribution_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000013I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• abnormal circulating amino acid level_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0005311I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• abnormal hair follicle morphology_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000377I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• postnatal growth retardation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001732I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• abnormal ovulation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0001928I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• decreased bone mineral density_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0000063I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• abnormal gait_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001406I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• enlarged sebaceous gland_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0000652I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• reduced female fertility_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0001923I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• decreased erythrocyte cell number_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0002875I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• premature aging_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0003786I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• anemia_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0001577I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• cachexia_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0005150I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• premature aging_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0003786I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• increased cellular sensitivity to oxidative stress_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0008412I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• abnormal cell death_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000313I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• cachexia_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0005150I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• white spotting_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0002938I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• osteoporosis_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0000066I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• increased cellular sensitivity to X-ray irradiation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0002879I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• osteoporosis_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000066I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• postnatal lethality, complete penetrance_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0011085I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs
• enlarged spleen_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• increased cellular sensitivity to ultraviolet irradiation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0008410I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhXpatm1HvsXpatm1HvsErcc2tm2ERCC2JhjhXpatm1Hvs