Peichuan. Zhang, et.al., The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas., Molecular and cellular biology, 2002, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/11997520

Peichuan. Zhang, et.al., The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas., Molecular and cellular biology, 2002, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Eif2ak3<tm1.2Drc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502572
• Eif2ak3<tm1Drc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2183829
• Eif2ak3<tm1.1Drc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774276

class

http://purl.org/net/cito/citesAsAuthority

• Eif2ak3<tm1.2Drc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502572
• Eif2ak3<tm1Drc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2183829
• Eif2ak3<tm1.1Drc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3774276

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperglycemia_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0001559I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal pancreatic alpha cell morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0005216I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• decreased bone mineralization_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0020137I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• decreased compact bone thickness_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0000135I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• impaired glucose tolerance_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0005293I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal axial skeleton morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0002114I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal osteoblast physiology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0005006I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• osteoporosis_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0000066I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• decreased body size_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0001265I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• postnatal lethality, incomplete penetrance_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0011086I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• absent pancreatic beta cells_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0009174I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal pancreatic acinar cell morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0009146I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal vertebrae development_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0005225I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• hypoactivity_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0001402I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal skeleton morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0005508I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal insulin secretion_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0003564I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal hindlimb morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0000556I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• exocrine pancreatic insufficiency_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0003335I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal compact bone morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0003797I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• absent pancreatic alpha cells_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0009178I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• increased liver glycogen level_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0010400I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• decreased pancreatic beta cell number_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0003339I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• prenatal lethality, incomplete penetrance_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0011101I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• hunched posture_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0001505I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal vertebral body morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0000141I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• small pancreatic islets_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0009172I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• decreased circulating insulin level_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0002727I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• postnatal growth retardation_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0001732I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc
• abnormal osteoblast morphology_Eif2ak3<tm1Drc>/Eif2ak3<tm1Drc>
  http://metadb.riken.jp/0004986I129S6SvEvTacEif2ak3tm1DrcEif2ak3tm1DrcEif2ak3tm1Drc