Benoit I. Giasson, et.al., Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein., Neuron, 2002, 34

http://rdf.ncbi.nlm.nih.gov/pubmed/12062037

Benoit I. Giasson, et.al., Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein., Neuron, 2002, 34

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-SNCA)20Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3530000
• Tg(Prnp-SNCA)7Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3805701
• Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3057167

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Prnp-SNCA)20Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3530000
• Tg(Prnp-SNCA)7Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3805701
• Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/db/mgi_rdf/MGI:3057167

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001263IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• tremors_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0000745IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• abnormal spinal nerve morphology_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001077IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• no abnormal phenotype detected_Tg(Prnp-SNCA)20Vle/0
  http://metadb.riken.jp/0002169IC3HC57BL6TgPrnpSNCA20Vle0TgPrnpSNCA20Vle
• abnormal gastrocnemius morphology_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0003082IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• abnormal gait_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001406IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• abnormal nervous system morphology_Tg(Prnp-SNCA*A53T)83Vle/0
  http://metadb.riken.jp/0003632IC3HC57BL6TgPrnpSNCAA53T83Vle0TgPrnpSNCAA53T83Vle
• hunched posture_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001505IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• abnormal myelination_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0000920IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• weakness_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0000746IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• neurodegeneration_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0002229IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• aphagia_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001438IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• gliosis_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0002183IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• decreased grooming behavior_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001442IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• axon degeneration_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0005405IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• abnormal motor capabilities/coordination/movement_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0002066IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• alpha-synuclein inclusion body_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0008493IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• akinesia_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0002690IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• premature death_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0002083IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• no abnormal phenotype detected_Tg(Prnp-SNCA)20Vle/Tg(Prnp-SNCA)20Vle
  http://metadb.riken.jp/0002169IC3HC57BL6TgPrnpSNCA20VleTgPrnpSNCA20VleTgPrnpSNCA20Vle
• abnormal motor capabilities/coordination/movement_Tg(Prnp-SNCA*A53T)83Vle/0
  http://metadb.riken.jp/0002066IC3HC57BL6TgPrnpSNCAA53T83Vle0TgPrnpSNCAA53T83Vle
• impaired righting response_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0001523IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle
• paresis_Tg(Prnp-SNCA*A53T)83Vle/Tg(Prnp-SNCA*A53T)83Vle
  http://metadb.riken.jp/0000754IC3HC57BL6TgPrnpSNCAA53T83VleTgPrnpSNCAA53T83VleTgPrnpSNCAA53T83Vle